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  1. ACT for older people with treatment-resistant Generalised Anxiety Disorder (CONTACT-GAD)

    Overview

    Are you interested in taking part in a research study that aims to reduce anxiety in older people with chronic worry? 

    The purpose of this trial is to see if a new form of talking therapy called Acceptance and Commitment Therapy plus usual care can reduce anxiety in older people with chronic worry that has not improved after previous treatment compared to usual care alone.

    What is the study about?  ...

  2. Behavioural Activation for young people with depression in specialist CAMHS (BAY)

    Overview

    We want to find out if behavioural activation (BA) works for young people with low mood. There are a lot of keen therapists in Child and Adolescent Mental Health Services (CAMHS) who would like to give better help to young people but need more training. We would like to give these therapists training in our BA. We also want to find out if our BA is good value for money, how easy it is to use for young people, carers and clinicians, and if it can reduce long waits for other therapy.

    What is the study about? ...

  3. Parenting Intervention for Parents with Psychosis (PIPPA)

    Overview

    We want to find out if parents with psychosis are happy to use a self-help parenting programme, and if they find it helpful and easy to use. 

    What is the study about? ...

  4. Remote Approaches to Psychosocial Intervention Delivery (RAPID)

    Overview

    RAPID is a study using online and phone-based psychological support to help prevent psychiatric hospital admissions for those with suicidal thoughts. The RAPID trial aims to compare two remote interventions with the standard care people usually receive to find out how best to help those who experience suicidal thoughts, and if this can reduce admissions to hospital.

    What is the study about? ...

  5. The National Confidential Inquiry into Suicide and Safety in Mental Health (NCISH)

    Overview

    The National Confidential Inquiry into Suicide and Safety in Mental Health (NCISH) is an internationally unique project collecting in-depth information on all suicides in the UK since 1996.

    What is the study about? What are you trying to find out? ...

  6. TherapyMatch-D

    Overview

    We want to explore if matching certain subgroups of people with depression to a particular therapy would help patients.  In this pilot randomized controlled trial, we will randomly assign some Talking Therapies sites to an experimental group, and others to a control group.  The TherapyMatch-D computer programme will give a personalised treatment recommendation to some patients in the experimental group. 

    What is the study about?  ...

  7. Culturally-Adapted Family Intervention Study (CaFI)

    Overview

    This study is no longer looking for new participants but is still ongoing.

    Culturally-adapted Family Intervention (CaFI) is a talking therapy designed together with Black service users, their families and community members for people from African-Caribbean backgrounds experiencing psychosis.

    What is the study about?  ...

  8. Digital Assessment of Wellbeing for New Parents (DAWN-P)

    Overview

    This study is no longer looking for new participants but is still ongoing.

    DAWN-P is a study to help identify postnatal depression in new parents through the use of smartphone app. 

    What is the study about? What are you trying to find out? ...

  9. FReSH START study: Looking at new approaches for people who self-harm

    Overview

    This study is no longer looking for new participants but is still ongoing.

    This study is looking at ways of improving therapies so they are better at supporting people who self-harm. 

    What is the study about? What are you trying to find out? ...

  10. Investigating troriluzole as possible treatment for OCD

    Overview

    This study is no longer looking for new participants but is still ongoing.

    This research study is investigating troriluzole (BHV-4157) in participants with Obsessive Compulsive Disorder (OCD). A further study is aking place to evaluate how safe and well tolerated troriluzole is when administered as a single dse of 280mg over a long period of time. 

    What is the study about? What are you trying to find out? ...

  11. Perinatal compassion focused therapy for mothers with mental health difficulties (P-CFT)

    Overview

    The Community Mental Health Team is taking part in a research study to evaluate how compassion can help with your wellbeing and bonding with your baby.

    What is the study about? What are you trying to find out? ...

  12. Service configurations for psychosis

    Overview

    This study investigates which combinations of support and therapies are helpful for different people experiencing psychosis in order to improve services. 

    What is the study about? What are you trying to find out?  ...

  13. The STAR trial (Study of Trauma and Recovery)

    Overview

    This study is no longer looking for new participants but is still ongoing.

    The STAR trial is for people who have been through stressful or traumatic events that have had a lasting impact on them and have problems such as hearing, seeing or feeling things that others can’t, or who have worries about harm or persecution.

    What is the study about? ...

  14. Integrating smoking cessation treatment into online psychological care (ESCAPE ONLINE)

    Overview

    This study is no longer looking for new participants but is still ongoing.

    Combining stop smoking support with online mental health treatment via SilverCloud+.

    What is the study about? ...

  15. The CELIA clinical trial (Biogen 247AD201)

    Overview

    This study is no longer looking for new participants but is still ongoing.

    The CELIA clinical trial is researching a potential treatment for people with mild cognitive impairment due to Alzheimer’s disease or mild Alzheimer’s disease dementia by focusing on a protein called tau. Abnormal tangles of built-up tau protein can be considered a key sign of the disease. We want to understand if different doses of a study medication called BIIB080 could be safe and have an effect on the progression of Alzheimer’s disease.

    What is the study about? ...

  16. Antidepressants for the prevention of depression following first-episode psychosis (ADEPP)

    Overview

    This study aims to find out whether an antidepressant medication (sertraline) can reduce the risk of depression happening at all after first-episode psychosis (FEP), and whether preventing depression can improve recovery.

    What is the study about? ...

  17. Auditory Biomarkers of Healthy Ageing and Alzheimer's Disease (ABHAD)

    Overview

    We aim to help scientists and doctors understand how hearing and Alzheimer's disease (AD) are linked.

    What is the study about? ...

  18. The All-in-One Study

    Overview

    This research study tests how to use brain scans and blood tests together to diagnose the underlying causes of memory problems more accurately, and at an earlier stage than is currently possible. We are interested in detecting early changes in the brain due to vascular (blood vessel) disease and changes that may be associated with Alzheimer’s disease. We will test new Magnetic Resonance Imaging (MRI) methods and blood tests.

    What is the study about? ...

  19. Pharmacogenetics: Genetics in Mental Health (GEMS)

    Overview

    The purpose of this study is to see if genetic testing could be useful for patients who are currently taking or due to start taking an antidepressant, antipsychotic or mood stabilising medicine as treatment for a mental illness. We also seek to understand how genetic and environmental factors may lead to the onset of mental health problems.

    What is the study about? ...

  20. Evidencing the need for routine sensory motor assessment and support for autistic adults

    Overview

    We are looking to show the need for routine Sensory and Motor Difficulties (SMD) assessments and treatment for autistic people without learning disability (LD) and what kinds of support would be of help, leading towards an innovative new SMD pathway for them.

    What is the study about? ...

  21. A multi-centre investigation of increasing alcohol abstinence with ketamine-assisted psychological therapy in severe alcohol use disorder (MORE-KARE)

    Overview

    Breaking Free Online is an internet-based, computerised treatment programme which is designed to help people to understand what may be driving their drug or alcohol use. The programme is designed to help people to learn to use psychological techniques to help them cope and control their drug or alcohol use and make positive changes to their lifestyle and health.

    What is the study about? ...

  22. Eating Disorders Genetics Initiative (EDGI)

    Overview

    EDGI is a project set up to explore genetic and environmental risk factors in individuals who have experienced or been diagnosed with an eating disorder. We want to understand how genetic and environmental risk factors influence eating disorders.

    Together, with your contribution, we can make a difference and improve future treatments! 

    What is the study about? ...

  23. Improving Access to Psychological Therapies for Children with Distressing Sensory Experiences (CHuSE)

    Overview

    In the ChUSE Interventions, we are offering a brief psychological therapy to help young people (8-15-years-old) with distressing sensory experiences, with  accompanying parent-workshops. You could be assigned either to our trial group or our treatment as usual group.

    What is the study about? ...

  24. Genetic Links to Anxiety and Depression (GLAD)

    Overview

    The Genetic Links to Anxiety and Depression (GLAD) Study is a project set up to support studies exploring risk factors for depression and/or anxiety. Our aim is to collect the psychological, medical, and genetic information of 40,000 people with experience of anxiety and depression.

    We also want to recruit 10,000 individuals without any history of mental disorder to help us explore why some people do and some people don’t become ill. This will help us to better understand the role both our genes and environment play in the development of these illnesses. 

    What is the study about? ...

  25. Semaglutide in people with early Alzheimer's Disease (EVOKE and EVOKE plus)

    Overview

    This study is no longer looking for new participants but is still ongoing.

    We are doing this study to see if the new medicine called semaglutide can help people with early Alzheimer’s disease. This will be done by comparing semaglutide against placebo on the effect on cognition (memory and other brain functions) and daily functioning.

    What is the study about? What are you trying to find out? ...

  26. Stratification of sporadic Alzheimer’s disease for drug discovery II (StrataStem)

    Overview

    StrataStem Ltd specialises in the cell biology of Alzheimer’s disease and is looking at new methods of early diagnosis and in identifying new drugs to treat the disease. The aim of the study is to create new neurons (brain cells). This will then allow us to study the genes involved in dementia. The overall aim of the research is to help us understand the biology behind Alzheimer’s disease and, potentially, identify new drugs to treat the disease.

    What is the study about? ...

  27. The RESTART trial: psychological therapies for trauma in people with an At Risk Mental State

    Overview

    We are conducting a new clinical trial to see if it would be useful to offer Eye Movement Desensitisation and Reprocessing (EMDR) and Trauma Focussed Cognitive Behavioural Therapy (TF-CBT), for people who have experienced distressing life events and psychological difficulties. 

    What is the study about?  ...

  28. Bipolar at Risk Trial II (BART II)

    Overview

    We are looking for people who may be at high risk of developing Bipolar Disorder (BD) to take part in a research trial looking at the possible benefits of Cognitive Behavioural Therapy (CBT) to help with difficulties associated with high and/or low mood.

    What is the study about? ...

  29. A multi-site randomised controlled trial to evaluate the impact of a group treatment for antenatal anxiety (ACORN-II)

    Overview

    We want to see whether a group-based therapy that we developed and tested — called CALM — improves anxiety in pregnant individuals during pregnancy and if it has long-term effects up to a year after the baby is born. 

    What is the study about?  ...

  30. Breaking Free Online vs Standard Treatment in Substance Use Disorder: Telehealth Model

    Overview

    Breaking Free Online is an internet-based, computerised treatment programme which is designed to help people to understand what may be driving their drug or alcohol use. The programme is designed to help people to learn to use psychological techniques to help them cope and control their drug or alcohol use and make positive changes to their lifestyle and health.

    What is the study about? ...

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