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  1. ACT for older people with treatment-resistant Generalised Anxiety Disorder (CONTACT-GAD)

    Overview

    Are you interested in taking part in a research study that aims to reduce anxiety in older people with chronic worry? 

    The purpose of this trial is to see if a new form of talking therapy called Acceptance and Commitment Therapy plus usual care can reduce anxiety in older people with chronic worry that has not improved after previous treatment compared to usual care alone.

    What is the study about?  ...

  2. Avoidable harm in prison healthcare

    Overview

    This study is no longer looking for new participants but is still ongoing.

    This study seeks to understand the scale and nature of avoidable harm in prison healthcare.

    What is the study about? ...

  3. Behavioural Activation for young people with depression in specialist CAMHS (BAY)

    Overview

    We want to find out if behavioural activation (BA) works for young people with low mood. There are a lot of keen therapists in Child and Adolescent Mental Health Services (CAMHS) who would like to give better help to young people but need more training. We would like to give these therapists training in our BA. We also want to find out if our BA is good value for money, how easy it is to use for young people, carers and clinicians, and if it can reduce long waits for other therapy.

    What is the study about? ...

  4. CONNECT: Using smart devices to predict relapse of psychosis

    Overview

    CONNECT is a study using digital technology to see if we can detect in advance if someone’s mental health might be getting worse.

    What is the study about?  ...

  5. Evaluation of the Alcohol Assertive Outreach Team Model (VALOR)

    Overview

    This study is no longer looking for new participants but is still ongoing. 

    This study aims to find out how Alcohol Assertive Outreach Teams (AAOT) services were first set up and how well they run. For this purpose, two experienced researchers will interview service users, staff, and other key people about their experiences with AAOT. 

    What is the study about? ...

  6. Genetic Links to Anxiety and Depression (GLAD)

    Overview

    The Genetic Links to Anxiety and Depression (GLAD) Study is a project set up to support studies exploring risk factors for depression and/or anxiety. Our aim is to collect the psychological, medical, and genetic information of 40,000 people with experience of anxiety and depression.

    We also want to recruit 10,000 individuals without any history of mental disorder to help us explore why some people do and some people don’t become ill. This will help us to better understand the role both our genes and environment play in the development of these illnesses. 

    What is the study about? ...

  7. Parenting Intervention for Parents with Psychosis (PIPPA)

    Overview

    We want to find out if parents with psychosis are happy to use a self-help parenting programme, and if they find it helpful and easy to use. 

    What is the study about? ...

  8. Prevalence of pathogenetic antibodies in psychosis (PPiP2)

    Overview

    There is some evidence that some cases of psychosis may be caused by a specific problem with the immune system. The immune system normally controls our ability to fight infection. If the immune system goes wrong it may cause condition called ‘autoimmune’ diseases. We can diagnose some of these diseases using blood tests.

    This study aims to see how many people with psychosis may have this specific problem with their immune system. We can find out that by testing your blood sample for specific antibodies. 

    What is the study about? ...

  9. Remote Approaches to Psychosocial Intervention Delivery (RAPID)

    Overview

    RAPID is a study using online and phone-based psychological support to help prevent psychiatric hospital admissions for those with suicidal thoughts. The RAPID trial aims to compare two remote interventions with the standard care people usually receive to find out how best to help those who experience suicidal thoughts, and if this can reduce admissions to hospital.

    What is the study about? ...

  10. Stratification of sporadic Alzheimer’s disease for drug discovery II (StrataStem)

    Overview

    StrataStem Ltd specialises in the cell biology of Alzheimer’s disease and is looking at new methods of early diagnosis and in identifying new drugs to treat the disease. The aim of the study is to create new neurons (brain cells). This will then allow us to study the genes involved in dementia. The overall aim of the research is to help us understand the biology behind Alzheimer’s disease and, potentially, identify new drugs to treat the disease.

    What is the study about? ...

  11. Talking with Voices II

    Overview

    Talking With Voices (TwV) is a new form of therapy that comes from the work of the International Hearing Voices Movement. It is based on the idea that what voices say may reflect real-life conflicts and difficulties in the life of the voice hearer. 

    What is the study about? ...

  12. The National Confidential Inquiry into Suicide and Safety in Mental Health (NCISH)

    Overview

    The National Confidential Inquiry into Suicide and Safety in Mental Health (NCISH) is an internationally unique project collecting in-depth information on all suicides in the UK since 1996.

    What is the study about? What are you trying to find out? ...

  13. The RESTART trial: psychological therapies for trauma in people with an At Risk Mental State

    Overview

    We are conducting a new clinical trial to see if it would be useful to offer Eye Movement Desensitisation and Reprocessing (EMDR) and Trauma Focussed Cognitive Behavioural Therapy (TF-CBT), for people who have experienced distressing life events and psychological difficulties. 

    What is the study about?  ...

  14. TherapyMatch-D

    Overview

    We want to explore if matching certain subgroups of people with depression to a particular therapy would help patients.  In this pilot randomized controlled trial, we will randomly assign some Talking Therapies sites to an experimental group, and others to a control group.  The TherapyMatch-D computer programme will give a personalised treatment recommendation to some patients in the experimental group. 

    What is the study about?  ...

  15. Assessing the Clinical and cost-Effectiveness of inpatient mental health Rehabilitation services provided by the NHS and independent sector (ACER)

    Overview

    The study aims to assess the effectiveness of NHS and independent sector inpatient mental health rehabilitation services.

    What is the study about? ...

  16. Culturally-Adapted Family Intervention Study (CaFI)

    Overview

    This study is no longer looking for new participants but is still ongoing.

    Culturally-adapted Family Intervention (CaFI) is a talking therapy designed together with Black service users, their families and community members for people from African-Caribbean backgrounds experiencing psychosis.

    What is the study about?  ...

  17. Digital Assessment of Wellbeing for New Parents (DAWN-P)

    Overview

    This study is no longer looking for new participants but is still ongoing.

    DAWN-P is a study to help identify postnatal depression in new parents through the use of smartphone app. 

    What is the study about? What are you trying to find out? ...

  18. FReSH START study: Looking at new approaches for people who self-harm

    Overview

    This study is no longer looking for new participants but is still ongoing.

    This study is looking at ways of improving therapies so they are better at supporting people who self-harm. 

    What is the study about? What are you trying to find out? ...

  19. Improving long-term benefits for depression and anxiety (CO-IMPROVE)

    Overview

    This research project aims to improve long-term benefits for patients that have received low intensity treatment for depression and/or anxiety in Improving Access to Psychological Therapies (IAPT) services. 

    What is the study about?  ...

  20. Investigating troriluzole as possible treatment for OCD

    Overview

    This study is no longer looking for new participants but is still ongoing.

    This research study is investigating troriluzole (BHV-4157) in participants with Obsessive Compulsive Disorder (OCD). A further study is aking place to evaluate how safe and well tolerated troriluzole is when administered as a single dse of 280mg over a long period of time. 

    What is the study about? What are you trying to find out? ...

  21. MCT-PATHWAY

    Overview

    This study is no longer looking for new participants but is still ongoing.

    The MCT Pathway programme ran from 2014 to 2021. Its goal was to improve the health and quality of life of heart disease patients and to reduce the risk of further cardiac events through cardiac rehabilitation services.

    What is the study about?  ...

  22. Perinatal compassion focused therapy for mothers with mental health difficulties (P-CFT)

    Overview

    The Community Mental Health Team is taking part in a research study to evaluate how compassion can help with your wellbeing and bonding with your baby.

    What is the study about? What are you trying to find out? ...

  23. Polygene algorithm for weight gain in first episode psychosis (PolyX)

    Overview

    This study is no longer looking for new participants but is still ongoing.

    We are carrying out a research project to study whether a person’s genetics may cause people to gain weight when taking anti-psychotic medication. This will enable us to target interventions at those individuals at greatest risk of gaining weight. A patient's genetic profile may also be used to make informed choices about the best medication to prescribe as well as targeting individuals with lifestyle interventions. Together, these advances could help reduce the risk of patients with psychosis developing obesity, diabetes, and heart disease (CVD) in the future.

    What is the study about? What are you trying to find out? ...

  24. Semaglutide in people with early Alzheimer's Disease (EVOKE and EVOKE plus)

    Overview

    This study is no longer looking for new participants but is still ongoing.

    We are doing this study to see if the new medicine called semaglutide can help people with early Alzheimer’s disease. This will be done by comparing semaglutide against placebo on the effect on cognition (memory and other brain functions) and daily functioning.

    What is the study about? What are you trying to find out? ...

  25. Service configurations for psychosis

    Overview

    This study investigates which combinations of support and therapies are helpful for different people experiencing psychosis in order to improve services. 

    What is the study about? What are you trying to find out?  ...

  26. The STAR trial (Study of Trauma and Recovery)

    Overview

    This study is no longer looking for new participants but is still ongoing.

    The STAR trial is for people who have been through stressful or traumatic events that have had a lasting impact on them and have problems such as hearing, seeing or feeling things that others can’t, or who have worries about harm or persecution.

    What is the study about? ...

  27. Bipolar at Risk Trial II (BART II)

    Overview

    We are looking for people who may be at high risk of developing Bipolar Disorder (BD) to take part in a research trial looking at the possible benefits of Cognitive Behavioural Therapy (CBT) to help with difficulties associated with high and/or low mood.

    What is the study about? ...

  28. Integrating smoking cessation treatment into online psychological care (ESCAPE ONLINE)

    Overview

    This study is no longer looking for new participants but is still ongoing.

    Combining stop smoking support with online mental health treatment via SilverCloud+.

    What is the study about? ...

  29. Prevention of suicide behaviour in prison: enhancing access to therapy (PROSPECT)

    Overview

    We have developed the PROSPECT programme for people in prison who may be at risk of suicide. The aim of the programme is to help prevent suicide in prisons. We are currently conducting research to find out if the PROSPECT programme is effective. 

    What is the study about? ...

  30. PrisScope: Self-harm in men's prisons

    Overview

    The purpose of this study is to gather information about self-harm in prison and to understand your views on interventions (treatments or help) that may be helpful. The aim is to help develop future interventions for men who self-harm in prison.

    What is the study about? What are you trying to find out? ...

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